Daxxify in Scottsdale, AZ
Daxxify injections in Scottsdale: lasts up to 6 months. $6/unit at Desert Bloom. Compare with Botox & Dysport. Dr. Borakowski, NMD. Free consultation.
Cost$6/unitProcedure time15 min
Key facts about Daxxify
Daxxify is the first peptide-powered neurotoxin FDA-approved for frown lines, with a median duration of six months, roughly twice as long as conventional options. Results appear within 1–2 days, treatment takes ~15 minutes, and most patients return to their day immediately.
Daxxify is one of three botulinum toxin treatments offered at Desert Bloom, alongside Botox and Dysport.
What is Daxxify?
You already know Botox works. You just wish it lasted longer. Every three months, the same cycle: the lines return, you book another appointment, you rearrange your schedule. If you travel frequently, have a busy season at work, or simply want fewer touch-ups, Daxxify may be worth considering.
Daxxify (daxibotulinumtoxinA-lanm) is an FDA-approved injectable neurotoxin for treating moderate to severe frown lines, the vertical creases between the eyebrows known as glabellar lines.
Daxxify lasts a median of 24 weeks (approximately six months), compared to three to four months for conventional neurotoxins like Botox and Dysport. For patients who are tired of rebooking every three to four months, that longer interval is often the main draw. Daxxify also contains no human or animal byproducts, making it the first vegan-friendly neurotoxin option. At Desert Bloom Skin Care in Scottsdale, Daxxify is available at $6 per unit with a complimentary assessment.
On the formulation side: Daxxify was approved by the FDA on September 7, 2022 (BLA 761127), and is the first botulinum toxin to use a synthetic peptide stabilizer instead of human serum albumin, the blood-derived protein found in Botox and Dysport. Daxxify uses Peptide Exchange Technology to achieve its longer duration.
How Daxxify Works: Peptide Technology Without Human Serum Albumin
All botulinum toxin products block acetylcholine release at the neuromuscular junction, temporarily reducing muscle contraction. The muscle still functions. It simply contracts less forcefully, and the overlying wrinkles soften.
A study published in early 2026 showed that the Daxxify peptide also binds to dermal cells called fibroblasts, stimulating the release of hyaluronic acid. Most patients notice this as dewy, hydrated skin, the “Daxxi glow.”
There are several ways Daxxify differs from conventional neurotoxins, and it is helpful to understand these differences. The most significant is its stabilizer. Traditional neurotoxins like Botox and Dysport use human serum albumin (a protein derived from human blood) to prevent the toxin from degrading. Daxxify replaces this with RTP004, a synthetic 35-amino-acid peptide that stabilizes the neurotoxin through strong electrostatic bonds. Besides protecting the product in the vial, the peptide enhances binding of the neurotoxin to neuronal cell surfaces, which may increase the likelihood of internalization by prolonging contact with the SV2 receptor. Greater internalization of botulinum toxin molecules correlates with longer duration of effect. This gives a neurotoxin that lasts roughly twice as long without requiring human- or animal-derived ingredients.
Among the Fastest-Acting Neurotoxins Available
In clinical studies, Daxxify showed visible results within approximately two days, generally faster than Dysport (two to three days) and Botox (four to seven days) based on available Phase 2 and Phase 3 data. Full effect typically develops over one to two weeks. If you are planning treatment before an event or trip, that earlier onset can be a practical consideration. Even so, the final settled result should still be evaluated at the two-week mark, the same as any neurotoxin.
Daxxify Treatment Areas
Daxxify is FDA-approved for one cosmetic indication: moderate to severe glabellar lines (frown lines). All other treatment areas are off-label, performed at the provider’s clinical judgment based on anatomy and extrapolation from other botulinum toxin products. At Desert Bloom, Dr. Borakowski plans the injection placement and dosage to your specific anatomy, not a fixed template.
Upper Face
- Frown lines (glabellar): 40 units. The vertical “11” lines between the eyebrows. This is the only FDA-approved cosmetic indication for Daxxify, with the strongest clinical evidence for duration.
- Forehead lines: approximately 32–40 units. Off-label use. Phase 2 data showed a median duration of 20.9 weeks for forehead wrinkles, with 96% of patients achieving none or mild severity at Week 4. Off-label, not FDA-approved for this area.
- Crow’s feet: approximately 48 units. Off-label use. Phase 2 data showed a median duration of 24.9 weeks with a 92% response rate at Week 4. Off-label, not FDA-approved for this area.
Lower Face and Specialty Areas
- Masseter reduction (jaw slimming): 24–30 units per side. Most patients need the standard dose of 24 units per side; up to 30 units per side is a very high dose and is rarely needed. Used to slim a square jawline or relieve TMJ-related clenching. Daxxify’s longer duration may reduce the frequency of retreatments in select patients, though individual response varies. Off-label, not FDA-approved for this area.
- Lip flip: approximately 4–8 units applied along the upper lip border to gently roll the lip outward for a subtly fuller appearance without filler. May be considered for patients interested in a longer-lasting lip flip, based on provider assessment. Off-label, not FDA-approved for this area.
No manufacturer dosing guidelines exist for off-label areas. All off-label applications are based on clinical judgment and individualized assessment.
Daxxify Dosing and Cost by Area
| Treatment Area | Units | Cost at $6/unit | FDA Status |
|---|---|---|---|
| Frown lines (glabellar) | 40 | $240 | FDA-approved |
| Forehead lines | ~32 | $144–$240 | Off-label |
| Crow’s feet (both sides) | 32–48 | $192–$288 | Off-label |
| Lip flip | 4–8 | $24–$48 | Off-label |
| Masseter / jaw (both sides) | 48–60 total | $288–$360 | Off-label |
| Full upper face | 80–128 | $480–$768 | Mixed |
Wondering if Daxxify suits your skin? Book a consultation with Dr. Natalya Borakowski, NMD
Who is a good candidate for Daxxify?
Ideal Candidate Profile
Patients who may benefit most from Daxxify
- Dynamic wrinkles that appear or deepen with facial expressions. Static lines visible at rest need a different approach
- Current Botox or Dysport user who finds that results wear off too quickly and is seeking longer duration between treatments
- Good overall health with no neuromuscular conditions
- Preference for vegan formulation with no animal-derived proteins
- Realistic expectations: softening, not total erasure
- Not pregnant or breastfeeding
- Seeking fewer maintenance visits per year
Candidacy is not determined by age alone. Many patients use Daxxify to reduce the frequency of their neurotoxin appointments, while others benefit from starting neurotoxin treatment in their late 20s to prevent lines from becoming etched at rest. Others may not need treatment until their 40s. The decision depends on your anatomy, your goals and, importantly, whether a longer-lasting results profile is an advantage or a limitation. Because Daxxify lasts up to six months, any unwanted effects also persist longer than with shorter-acting products. For first-time neurotoxin patients, Dr. Borakowski evaluates each case individually. Some patients may benefit from starting with a shorter-acting product like Botox, while others are good candidates for Daxxify from the start.
When Daxxify May Not Be Right for You
All botulinum toxin products carry an FDA boxed warning for the risk of distant spread of toxin effect, which can cause swallowing and breathing difficulties. No serious distant-spread events were reported in clinical studies at the 40-unit glabellar dose (FDA Prescribing Information).
“Longer-lasting does not always mean better. It means the decision to treat requires more certainty that it is the right treatment for the right patient,” says Dr. Borakowski.
What to expect during Daxxify
A Daxxify appointment at Desert Bloom takes about 15 minutes. Dr. Borakowski assesses your face first, then injects with a small needle. For frown lines, the standard dose is 40 units across 5 injection sites, which costs $240 at $6 per unit. Most patients go straight back to their day afterwards.
- Assessment: complimentary. Dr. Borakowski checks how your muscles move and decides whether Daxxify or a shorter-acting product such as Botox suits you better, especially if this is your first neurotoxin treatment.
- Injection: frown lines are the FDA-approved area. Forehead lines (about 32 units) and crow’s feet (about 48 units) are off-label and dosed to your anatomy.
- Aftercare: stay upright for 4 hours, do not rub the area for 24 hours, skip strenuous exercise for 24 hours and avoid saunas, hot tubs and heat for 48 hours. Your normal skincare is fine.
Minor swelling, redness or bruising at the injection points usually settles within hours. Results start to show within 1 to 2 days.
What results can you expect from Daxxify?
Most patients notice improvement within approximately 48 hours, generally earlier than other available neurotoxins based on clinical data. Treated muscles begin to relax and frown lines start to soften.
The neurotoxin reaches its peak effect. Frown lines, forehead wrinkles, and crow’s feet (if treated) appear visibly smoother. This is when results should be evaluated.
Results are at their strongest. The treated muscles remain relaxed. Lines are softened or absent depending on their depth before treatment.
Muscle activity slowly returns as the body regenerates nerve terminals. Lines may begin to reappear but remain softer than baseline.
Most patients schedule their next appointment around the six-month mark. In clinical trials, 25% of subjects had not returned to moderate or severe severity at Week 32.
Daxxify Before and After
Typical results include visibly smoother frown lines, a relaxed forehead, and preserved natural expression.
Patients who have used Botox or Dysport previously often report that in many ways the results feel similar in quality but persist noticeably longer. Some patients report that the treated skin appears smoother beyond wrinkle reduction, an observation sometimes referred to as the “Daxxify glow.” This has not been formally studied, and may simply reflect the visual effect of relaxed muscles on overlying skin texture.
Limitations to know: Daxxify does not improve skin texture, volume loss, or sun damage. These are separate concerns addressed by separate treatments: RF microneedling for texture, dermal fillers for volume. Daxxify addresses one thing precisely: muscle-driven facial wrinkles.
Daxxify at Desert Bloom
Price: $6/unit. Your consultation covers your goals, the plan and the exact cost before anything is booked.
What is recovery like after Daxxify, and what are the risks?
Recovery and Aftercare
Daxxify injections require minimal downtime. Most patients return to normal activities immediately after treatment.
The drug is injected using a small needle at five standard injection sites for glabellar lines. The aftercare protocol is the same as other neurotoxin injections:
- Remain upright for 4 hours after treatment
- Avoid rubbing or touching the treated area for 24 hours
- No strenuous exercise for 24 hours
- Avoid saunas, hot tubs, or excessive heat for 48 hours
- Minor swelling, redness, or bruising may occur at injection sites and typically resolves within hours
- You can use your regular skincare products. There are no special restrictions
Contact Desert Bloom if you experience eyelid drooping, difficulty swallowing, or any unusual symptoms after treatment. Because Daxxify lasts longer than Botox or Dysport, any side effects, though typically mild, may also persist for a longer period.
Side Effects, Safety, and Clinical Trials
What Clinical Trials Show
Daxxify’s safety is supported by its clinical trial program, which included over 2,700 patients across ~4,200 treatments.
Investigator assessments showed high response rates across all three pivotal trials.
Common side effects from the pivotal trials include headache (approximately 6%) and injection site reactions such as pain, redness, swelling, and bruising (approximately 6%). Eyelid ptosis occurred in approximately 2% of patients in the pivotal trials and 0.9% per treatment cycle in a larger open-label study. Overall, 17.8% of patients in that open-label study experienced treatment-related adverse events, generally mild and self-resolving.
An important finding: zero out of 2,737 evaluable patients developed neutralizing antibodies across the entire clinical trial program. This is notable because neutralizing antibodies can reduce a neurotoxin’s effectiveness over time, which is a concern with repeat treatments.
Because Daxxify lasts longer than conventional neurotoxins, if side effects do occur, they may also take longer to resolve. This follows from its extended duration of effect and is not a safety concern unique to Daxxify.
Notably, the clinical trial program reported zero cases of neutralizing antibody formation across 2,737 evaluable subjects. Neutralizing antibodies can reduce a neurotoxin’s effectiveness over years of repeated use, which is a concern with all botulinum toxin products. The absence of antibody formation in a study of this size is a meaningful data point, though longer-term post-marketing data will provide a more complete picture.
Questions about downtime or aftercare? Call us on (480) 567-8180
How does Daxxify compare with other treatments?
Daxxify vs Botox vs Dysport
Daxxify, Botox, and Dysport are all botulinum toxin type A neurotoxins that block muscle contraction to smooth dynamic wrinkles. The differences are clinically meaningful: Daxxify lasts a median of six months (versus three to four for Botox and Dysport), uses a synthetic peptide stabilizer instead of human serum albumin, and generally shows the earliest onset at approximately two days based on available data. Botox has the longest clinical track record with 20+ years of data and the broadest FDA-approved indications. Dysport diffuses more broadly, which can be advantageous for larger areas like the forehead. In clinical trials, Daxxify demonstrated a median duration of 24 weeks with no patients developing neutralizing antibodies across 2,737 evaluable subjects. Unit dosing differs between products. Daxxify uses 40 units for frown lines versus 20 units of Botox, but units are not interchangeable across brands. At Desert Bloom Skin Care in Scottsdale, Dr. Borakowski offers all three and recommends based on your anatomy and goals.
| Feature | Daxxify | Botox | Dysport |
|---|---|---|---|
| Active Ingredient | DaxibotulinumtoxinA-lanm | OnabotulinumtoxinA | AbobotulinumtoxinA |
| FDA Approval (Cosmetic) | 2022 | 2002 | 2009 |
| Stabilizer | Synthetic peptide (no HSA) | Human serum albumin | Human serum albumin + lactose |
| Onset | ~2 days | 4–7 days | 2–3 days |
| Duration | 6 months median (up to 9) | 3–4 months | 3–4 months |
| Glabellar Dose | 40 Units | 20 Units | 50 Units |
| Injection Sites | 5 (same pattern) | 5 (same pattern) | 5 (same pattern) |
| Vegan | Yes | No | No |
| Price at Desert Bloom | $6/unit | $11.50/unit | $4/unit |
| Best For | Patients wanting longer intervals between visits | Precise and predictable, with the broadest evidence base | Broader areas like forehead; faster onset than Botox |
Daxxify does last longer. Clinical trial data shows a median of 24 weeks. But longer is not automatically better for everyone. Botox has 20+ years of clinical data, a broader range of FDA-approved indications, and a shorter duration that gives you more flexibility to adjust between treatments. If you already know how you respond to neurotoxin and want fewer appointments, Daxxify is worth considering. If you are newer to neurotoxin or prefer to fine-tune your results more often, Botox may be the more practical starting point. A consultation helps sort through those trade-offs for your specific situation.
A note on units: Daxxify uses 40 units for glabellar lines versus 20 units of Botox, but units are not interchangeable. Each product defines its units based on its own potency assay. See the cost section below for conversion ratios and annual pricing comparisons.
Combination Treatments
Daxxify addresses muscle-driven wrinkles. For a fuller result, it works alongside other treatments rather than as a standalone solution for every concern.
Combination Treatments
Daxxify relaxes the muscles that create dynamic wrinkles; fillers restore lost volume in the cheeks, temples, or under-eye area. Together they form the foundation of a non-surgical approach to facial aging. Many patients combine both in a single visit.
Learn moreDaxxify smooths dynamic lines from above; RF microneedling improves skin texture, pores, and firmness from below. Schedule RF microneedling first, then Daxxify 2–3 weeks later for optimal results.
Learn moreDaxxify for the upper face (forehead, frown lines, crow’s feet) combined with PDO thread lifting for mid and lower face. A thread brow lift can complement Daxxify by adding structural support where neurotoxin alone may not be enough. In many cases, neurotoxin treatment is scheduled approximately 2 weeks before a thread procedure so opposing muscles are relaxed, though timing varies by anatomy and provider protocol.
Learn moreWho performs Daxxify at Desert Bloom?
Many providers offer neurotoxins. What differs is who performs the injection, what options they carry, and whether they are willing to tell you when a different product, or no treatment at all, is the better choice.
Desert Bloom carries all three major neurotoxins. Dr. Borakowski typically recommends Daxxify for patients seeking 6-month intervals between visits, Botox for those who prefer shorter-acting treatment with more adjustment flexibility, and Dysport for broader diffusion across large foreheads. Every injection is performed by Dr. Borakowski or another licensed physician under her direct supervision. She has 18 years of experience in aesthetic medicine, holds a naturopathic medical degree from Southwest College of Naturopathic Medicine, and teaches aesthetic medicine to licensed practitioners as adjunct faculty at the University of Bridgeport.
This is a clinical aesthetics practice, not a volume-driven med spa. Transparent pricing ($6/unit, published). Individualized assessment. If Daxxify is not the right option, Dr. Borakowski will say so.
“Longer-lasting does not always mean better. It means the decision to treat requires more certainty that it is the right treatment for the right patient.”
Price
How much does Daxxify cost in Scottsdale?
- Daxxify$6/unit15 min
Daxxify Calculator
Each treatment area requires a different number of units, and the cost depends on your anatomy, not a fixed menu. Select your areas and see a personalized estimate at Desert Bloom’s current Daxxify rates.
At Desert Bloom Skin Care in Scottsdale, Daxxify costs $6 per unit, compared to $11.50 for Botox and $4 for Dysport.
A typical full upper face treatment uses 80–128 units, totaling $480–$768 per session. A common 100-unit treatment costs $600. Because Daxxify generally lasts longer than Botox, many patients find they need only two sessions per year instead of three or four. That brings the estimated annual cost to around $1,200 for a 100-unit treatment. That works out to roughly $100 per month compared to $144–$192 per month for Botox, depending on how often you retreat. Individual duration varies. Pricing at other providers typically ranges from $6–$12 per unit. Desert Bloom publishes all pricing openly, with no hidden fees or membership requirements.
Scottsdale pricing for neurotoxins ranges widely. Entry-level providers may offer lower per-unit rates, but the experience and credentials of the injector matter. At Desert Bloom, every injection is administered by Dr. Borakowski or another licensed physician under her direct supervision. Full pricing for all neurotoxins is on our complete treatment pricing page.
Daxxify Units vs Botox Units
Units are not interchangeable between neurotoxin products. Daxxify uses 40 units for glabellar lines compared to Botox’s 20 units, but this does not mean Daxxify is twice as potent. The products use different potency assays to define their units. Desert Bloom’s Neurotoxin Cost Calculator uses commonly referenced conversion ratios: Daxxify 2:1 to Botox, Dysport 3:1 to Botox. The calculator covers 14 treatment zones: forehead, glabella, crow’s feet, brow lift, bunny lines, lip lines, lip flip, chin, DAO, platysma, and masseter, with cost estimates based on Desert Bloom’s published pricing.
Members of the Desert Reset membership receive preferred pricing on many treatments. See the full price list.
Questions
Frequently asked questions
How long does Daxxify last?
A median of six months (24 weeks) in Phase 3 clinical trials, roughly twice as long as Botox or Dysport. Duration varies by metabolism, muscle mass, and treatment area.
How much does Daxxify cost?
At Desert Bloom, Daxxify is $6 per unit. A typical full upper face treatment (80–128 units) costs $480–$768, with most patients needing only two sessions per year.
Is Daxxify better than Botox?
Neither is universally better. Daxxify lasts longer and is vegan; Botox has 20+ years of data and allows more frequent adjustments.
What is the difference between Daxxify and Dysport?
Daxxify uses a synthetic peptide stabilizer and lasts approximately six months. Dysport uses human serum albumin, diffuses more broadly, and lasts three to four months.
Is Daxxify safe?
Yes. FDA-approved and studied in over 2,700 patients with zero cases of neutralizing antibody formation. Common side effects include headache (~6%) and eyelid ptosis (~2%), generally mild and self-resolving.
What are the side effects of Daxxify?
Most common: headache (~6%), injection site reactions (~6%), and eyelid ptosis (~2%). Because Daxxify lasts longer, side effects may also take longer to resolve.
Can I switch from Botox to Daxxify?
Yes. Most patients switch at their next scheduled appointment with no special waiting period beyond letting the previous treatment wear off.
How many units of Daxxify do I need?
Typical ranges: frown lines 40 units, forehead ~32, crow’s feet 32–48, full upper face 80–128 units. Use our Neurotoxin Cost Calculator for a personalized estimate.
Does Daxxify work for masseter reduction?
Yes, off-label, typically 24–30 units per side for jaw slimming or TMJ-related clenching. The longer duration may reduce retreatment frequency.
Is Daxxify vegan?
Yes. Daxxify is the first neurotoxin to use a synthetic peptide instead of human serum albumin, so it contains no human- or animal-derived proteins.
How long does Daxxify take to work?
Most patients see initial improvement within one to two days. Full effect develops over one to two weeks.
Is Daxxify more expensive than Botox?
Per session slightly higher (~$600 vs ~$575), but annual cost is often lower because Daxxify requires fewer sessions: roughly $1,200 vs $1,725–$2,300 for Botox.
Ready to talk it through? Book a consultation and we will look at your goals, explain your options and give you a clear plan and price.